O43791 - Speckle-type POZ protein

Protein
Speckle-type POZ protein
Gene
SPOP
Reference
UniProtKB reviewed (Swiss-Prot)
Amino acids
374
Disorder28.00%
LIP17.60%
Domain69.50%

Disorder
F
   
MobiDB-lite
P
   
AlphaFold-disorder (RSA)
P
Linear interacting peptide
F
Phase separation
F
....................................Missing residuesDisorderStructureObservedStructureObservedStructureObservedStructureDisorderObservedStructureObservedDisorderObservedDisorderStructureDisorderDisorderDisorderDisorderLipLipLipLipPhase separation150100150200250300350
F
Consensus
C
Curated
D
Derived
H
Homology
P
Predicted

AlphaFold O43791

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Annotation source Priority consensus
Coverage 21.9%
Disorder residues
Intrisically disordered residues
Curated | hasDbXref
Coverage 3.7%
Start 1 - End 14
Missing residues
Residues coordinates have not been reported in the PDB structure, likely because without a fixed structure
Derived | ECO:0007297
Coverage 67.4%
Observed residues
Experimentally observed residues in the PDB structure (X-ray, NMR, Cryo-EM)
Derived | ECO:0007297
Coverage 2.4%
Start 15 - End 23
Disorder residues
Intrisically disordered residues
Predicted | ECO:0008034
Coverage 4.5%
Structure
Structured residues
Predicted
M
S
R
V
P
S
P
P
P
10P
A
E
M
S
S
G
P
V
A
20E
S
W
C
Y
T
Q
I
K
V
30V
K
F
S
Y
M
W
T
I
N
40N
F
S
F
C
R
E
E
M
G
50E
V
I
K
S
S
T
F
S
S
60G
A
N
D
K
L
K
W
C
L
70R
V
N
P
K
G
L
D
E
E
80S
K
D
Y
L
S
L
Y
L
L
90L
V
S
C
P
K
S
E
V
R
100A
K
F
K
F
S
I
L
N
A
110K
G
E
E
T
K
A
M
E
S
120Q
R
A
Y
R
F
V
Q
G
K
130D
W
G
F
K
K
F
I
R
R
140D
F
L
L
D
E
A
N
G
L
150L
P
D
D
K
L
T
L
F
C
160E
V
S
V
V
Q
D
S
V
N
170I
S
G
Q
N
T
M
N
M
V
180K
V
P
E
C
R
L
A
D
E
190L
G
G
L
W
E
N
S
R
F
200T
D
C
C
L
C
V
A
G
Q
210E
F
Q
A
H
K
A
I
L
A
220A
R
S
P
V
F
S
A
M
F
230E
H
E
M
E
E
S
K
K
N
240R
V
E
I
N
D
V
E
P
E
250V
F
K
E
M
M
C
F
I
Y
260T
G
K
A
P
N
L
D
K
M
270A
D
D
L
L
A
A
A
D
K
280Y
A
L
E
R
L
K
V
M
C
290E
D
A
L
C
S
N
L
S
V
300E
N
A
A
E
I
L
I
L
A
310D
L
H
S
A
D
Q
L
K
T
320Q
A
V
D
F
I
N
Y
H
A
330S
D
V
L
E
T
S
G
W
K
340S
M
V
V
S
H
P
H
L
V
350A
E
A
Y
R
S
L
A
S
A
360Q
C
P
F
L
G
P
P
R
K
370R
L
K
Q
S
A
A
A
A
A
A

Interactors

Protein
  Accession GeneNamePDBs Contacts
Protein--823
O43791SPOPSpeckle-type POZ protein72154
Q15059BRD3Bromodomain-containing protein 31310
P70118PDX1Pancreas/duodenum homeobox protein 1516
Q9VHV8puc-48
Q12888TP53BP1TP53-binding protein 138
Q13618CUL3Cullin-3211
O75496GMNNGeminin29
P19538ciTranscriptional activator cubitus interruptus210
O75367MACROH2A1Core histone macro-H2A.129
P52945PDX1Pancreas/duodenum homeobox protein 1110
P60484PTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN15
DNA
  Accession GeneNamePDBs Contacts
Other
  Accession GeneNamePDBs Contacts
other--1913

Subcellular locations


Cross References