Current Version
MobiDB v1.2.1
Released August 28, 2012
MobiDB-xp: 26,933 experimentally annotated proteins.
MobiDB-full: 4,662,776 annotated proteins.
We've greatly expanded MobiDB's coverage! Check the news section for more details.
Contact info
MobiDB created and maintained by Tomas Di Domenico for the BioComputing Lab in the University of Padova, Italy.
For questions and/or comments, please use the contact form.
a database of protein disorder and mobility annotations
Help us shape the future of MobiDB! Click here to access the public BETA version of the upcoming MobiDB release.
Description of the database
Disordered protein regions are key for the function of numerous processes within an organism,
and the determination of the protein's biological role. The current most common sources for protein disorder annotations, DisProt and the PDB,
cover only a fraction of the available sequences in the SwissProt database and up to this date deal only with X-Ray resolved structures.
MobiDB's motivation is to build on the content provided by those sources and expand it, with the goal of providing a centralized source for
data on disordered regions in protein structures, featuring full coverage of
the SwissProt database.
Three different sources of raw data and four different flavors of disorder are included and available -featuring
a novel NMR mobility definition- and its flexible design makes the addition of extra annotating sources (e.g. mobility/disorder predictors)
a simple task.
Precalculated annotations from three disorder predictors (ESpritz, IUPred and DisEMBL) are also included to provide information in cases where experimental annotations
are not available.
Use cases
There are two main use cases for MobiDB: the first, analyzing a single protein and generating consensus annotations based on different sources of information. The second, generating a dataset of a protein ensemble of certain characteristics for offline analysis, which will include all available annotations.
Please refer to the help pages for tutorials and further details.
Citing MobiDB
In citing, please refer to: Tomás Di Domenico, Ian Walsh, Alberto J.M. Martin, and Silvio C.E. Tosatto: MobiDB: a comprehensive database of intrinsic protein disorder annotations. Bioinformatics. 2012 Aug 1;28(15):2080-1. Epub 2012 Jun 1.
Integrated resources
MobiDB uses resources from the following projects:
